Research Opportunities Database
Devasis Chatterjee
Assistant Professor of Medicine (Research)
Department: Medicine
Phone: +1 401 444 9039
Email: Devasis_Chatterjee@Brown.EDU
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Research Opportunities Database
Devasis ChatterjeeAssistant Professor of Medicine (Research) Department: MedicinePhone: +1 401 444 9039 Email: Devasis_Chatterjee@Brown.EDU Location:Phone:Research SummaryStudy the regulation of two proteins that directly affect tumor cell death (RKIP) and survival (STAT3). We have found that RKIP is a negative regulator of STAT3. We are validating if RKIP is a candidate to be utilized as the basis for molecular-targeted therapeutic strategy for cancer.Past or Present Projects Available:Inhibition of RKIP function by activated STAT3 in gastric cancer; Inhibition of STAT3 signaling by RKIP in breast cancer; Inhibition of Src-mediated activation of STAT3 by RKIP; Inhibition of EcM survival signaling by RKIP in breast cancer cells; Heliobacter pylori inhibits RKIP function via STAT3 activation and Snail induction in human gastric cancer cells; The Effect of Microvesicles on Breast Cancer Cell-specific Phenotypic Changes; The role of camptothecin and RKIP on STAT3 activation in human colon cancer cells |
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