Research Opportunities Database
Arthur Landy
Professor of Medical Science
Department: Molecular Biology, Cell Biology, & Biochemistry
Phone: +1 401 863 2571
Phone 2: +1 401 863 1658
Email: Arthur_Landy@Brown.EDU
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Research Opportunities Database
Arthur LandyProfessor of Medical Science Department: Molecular Biology, Cell Biology, & BiochemistryPhone: +1 401 863 2571 Phone 2: +1 401 863 1658 Email: Arthur_Landy@Brown.EDU Location:Sidney Frank Hall, Room 272 - 863-2571Research SummaryMechanism of site-specific recombination; protein-DNA interactions; structure of higher-order protein-DNA complexes.Past or Present Projects Available:Mechanism of holliday junction resolution by lambda integrase; Structural requirements for resolution of holliday junctions in a site specific recombination; Lambda integrase DNA binding specificity; DNA degradation activity of C-65, C-75 and intact integrace in the presence of Ng++; Isolating mutants affecting the catalytic function of integrase; Point mutations in conserved residues of the alpha site-specific recombinase; Determination of the number of integrase protomers required to resolve a holiday junction intermediate; Creation of a cystein-less mutant alpha integrase |
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