Research Opportunities Database
Jonathan Reichner
Associate Professor of Surgery (Research)
Department: Surgery
Phone: +1 401 444 8683
Email: Jonathan_Reichner@Brown.EDU
Location:
Phone: 444 8683Research Summary
Role of CR3 as a Pattern Recognition Receptor --Neutrophils bind to ß-glucan which is a cell wall component of infectious microorganisms including fungi. Since glucan does not occur in mammals, ß-glucan provides a recognition system for the immune system to distinguish a pathogen from self.
Chemotaxis: How Migrating Neutrophils Acquire a Sense of Direction --
To determine how beta-glucan increases the directional movement of human neutrophils.