Research Opportunities Database
Juan Sanchez-Esteban
Associate Professor of Pediatrics
Department: Pediatrics
Phone: +1 401 274 1122
Email: Juan_Sanchez-Esteban@Brown.EDU
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Research Opportunities Database
Juan Sanchez-EstebanAssociate Professor of Pediatrics Department: PediatricsPhone: +1 401 274 1122 Email: Juan_Sanchez-Esteban@Brown.EDU Location:401-274-1122x7483; jsanchezesteban@whri.orgResearch SummaryNormal lung growth and development during fetal life are critical for survival after birth. Premature infants are often born before sufficient lung maturation has occurred, and as a result, they experience a high rate of long term pulmonary complications. Understanding the mechanisms of fetal lung growth and development is a crucial step for design of preventive and therapeutic strategies. Mechanical forces generated in utero by repetitive breathing-like movements and by fluid distension of the fetal lung are essential for normal lung development. My laboratory is interested in understanding the mechanisms by which pulmonary cells sense these mechanical signals to promote lung maturation. Using knockout mouse models, stretch devices and explant lung tissues, we are investigating how different mechanosensors transmit signals into the ERK cascade to regulate stretch-induced epithelial cell differentiation.Past or Present Projects Available:Role of the Epidermal Growth Factor Receptor and its ligands in mechanical stretch-induced lung injury; Role of the Epidermal Growth Factor Receptor (EGFR) and its ligands in mechanical stretch-induced lung injury |
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