Research Opportunities Database
William Fairbrother
Associate Professor of Biology
Department: Molecular Biology, Cell Biology, & Biochemistry
Phone: +1 401 863 6215
Phone 2: +1 401 863 6215
Email: William_Fairbrother@brown.edu
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Research Opportunities Database
William FairbrotherAssociate Professor of Biology Department: Molecular Biology, Cell Biology, & BiochemistryPhone: +1 401 863 6215 Phone 2: +1 401 863 6215 Email: William_Fairbrother@brown.edu Location:70 Ship Street, Room 404 - 863-6215Research SummaryStudies RNA splicing. A third of all hereditary disease mutations affect RNA splicing. Using deep sequencing and array based synthesis, we are measuring the effects of thousands of mutations and SNPs on splicing, spliceosome assembly and RNA protein binding. In the lab there is a strong emphasis on developing hybrid approaches to science, combining genome analysis and computational biology with experimentationPast or Present Projects Available:Large Scaled Genomic Analysis of Gene Expression Signals; Cross-Species Conservation of Gene Splicing Signals; Building a Splicing Simulator; Further Characterization of Functional Elements-experimental identification of trans-acting factors; Identifying Functional SNPs (in the brain); Running red lights--a search for stop codes readthrough in Drosophila and human genomes; The effect of secondary structure formation on RNA splicing in fish genes; UV crosslinking analysis of PTB ligands; High-throughput investigation of transcription factor binding for gene regulation and splicing; The Effect of SNPs on Post-Transcriptional; Identification of SNPs that--in Interfering with RNA splicing, cause Human Disease |
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