Research Opportunities Database

Wayne Bowen

Wayne Bowen

Dept. Chair, Professor of Biology, Upjohn Professor of Pharmacology

Department: Molecular Pharmacology, Physiology & Biotechnology

Phone: +1 401 863 3253

Email: Wayne_Bowen@brown.edu

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Location:

BMC, Room 389 - 863-3253

Research Summary

Pharmacology and medicinal chemistry of sigma receptors and opioid receptors; signal transduction mechanisms in receptor-mediated apoptosis and regulation of cell proliferation.

Past or Present Projects Available:

Effects of Sigma-2 receptors on cellular calcium; Effects of Sigma-2 receptors on cellular sphingolipids; Signaling mechanisms of lysosphingolipids; Signaling mechanisms of ceramides; Effects of Sigma-2 receptors on mitochondrial function; Characterization of novel ligands for Sigma-2 receptors; The molecular basis of overproliferation in sigma-1 receptor transductants; Sigma-2 receptor triggered cell suicide and cellular mechanisms; Phytochemical and biological investigation of Triadenum fraserk c-marking St. John's Wort; Evaluating the cytotoxic effects of fractions of thermic oil on a pancreatic cancer cell; Effects of Sigma-2 receptor activation on pancreatic cancer cells and cellular apoptosis