Research Opportunities Database

Devasis Chatterjee

Assistant Professor of Medicine (Research)

Department: Medicine

Phone: +1 401 444 9039

Email: Devasis_Chatterjee@Brown.EDU

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Location:

401-444-9039; dchatter@lifespan.org

Research Summary

Study the regulation of two proteins that directly affect tumor cell death (RKIP) and survival (STAT3). We have found that RKIP is a negative regulator of STAT3. We are validating if RKIP is a candidate to be utilized as the basis for molecular-targeted therapeutic strategy for cancer.

Past or Present Projects Available:

Inhibition of RKIP function by activated STAT3 in gastric cancer; Inhibition of STAT3 signaling by RKIP in breast cancer; Inhibition of Src-mediated activation of STAT3 by RKIP; Inhibition of EcM survival signaling by RKIP in breast cancer cells; Heliobacter pylori inhibits RKIP function via STAT3 activation and Snail induction in human gastric cancer cells; The Effect of Microvesicles on Breast Cancer Cell-specific Phenotypic Changes; The role of camptothecin and RKIP on STAT3 activation in human colon cancer cells