Research Opportunities Database

Edward Hawrot

Edward Hawrot

Alva O. Way University Professor of Medical Science

Department: Molecular Pharmacology, Physiology & Biotechnology

Phone: +1 401 863 1034

Phone 2: +1 401 863 6086

Email: Edward_Hawrot@Brown.EDU

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70 Ship Street - 863-1034

Research Summary

Structure-function of the nicotinic acetylcholine receptor; site-directed mutagenesis of protein neurotoxins.

Past or Present Projects Available:

Construction of targeting vectors for knock-in gene replacements; Recombinant expression of neurotoxins and cardiotoxins; Structure/function studies of receptors; Site-Directed mutagenesis of alpha-neurotoxins; Structure-function and target site analysis of CTX III using recombinant DNA gene expression; The analysis and purification of authentic and recominant bungarotoxin; Recombinant expression of nicotinic receptor fragments; Site directed mutagenesis study of alpha-bungarotoxin; Direct expression of a synthetic gene for alpha-bungarotoxin in E. coli: HPLC and spectroscopy of receptor ligand proteins and alpha-bungarotoxin; Dimerization and specificity of recombinantly expressed chimeric neurotoxins