Research Opportunities Database

Conrad Johanson

Conrad Johanson

Professor Emeritus of Neurosurgery

Department: Neurosurgery

Phone: +1 401 885 2231

Phone 2: +1 401 688 5299

Email: Conrad_Johanson@Brown.EDU

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RI Hospital, Providence, RI 02903; 401-885-2231 or 401 688 5299

Research Summary

Alpert Medical School Professor of Neurosurgery, Conrad Johanson, investigates molecular and physiologic aspects of transporter mechanisms at the blood-brain-cerebrospinal fluid (CSF) interfaces that actively create an optimal chemical environment for neuronal functioning. In brain diseases and fluid disorders, pharmacologic remedies are needed to correct distortions in choroid plexus-CSF neurochemistry, in order to overcome cognitive deficits and other neural dysfunctions. Research goal: To restore CSF biochemical composition (homeostasis) and fluid dynamics disrupted by central nervous system pathology. Preserving a functional CSF circulation throughout aging helps to maintain cerebral metabolism, neurotransmission and sound cognition.

Past or Present Projects Available:

The expression of aquaporin-1 and acuaporin-4 in the aging brain; Neurogenic region expression of protein receptors and transporters in the aging rat model of Alzheimer's Disease