Research Opportunities Database

Juan Sanchez-Esteban

Associate Professor of Pediatrics

Department: Pediatrics

Phone: +1 401 274 1122

Email: Juan_Sanchez-Esteban@Brown.EDU

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Location:

401-274-1122x7483; jsanchezesteban@whri.org

Research Summary

Normal lung growth and development during fetal life are critical for survival after birth. Premature infants are often born before sufficient lung maturation has occurred, and as a result, they experience a high rate of long term pulmonary complications. Understanding the mechanisms of fetal lung growth and development is a crucial step for design of preventive and therapeutic strategies. Mechanical forces generated in utero by repetitive breathing-like movements and by fluid distension of the fetal lung are essential for normal lung development. My laboratory is interested in understanding the mechanisms by which pulmonary cells sense these mechanical signals to promote lung maturation. Using knockout mouse models, stretch devices and explant lung tissues, we are investigating how different mechanosensors transmit signals into the ERK cascade to regulate stretch-induced epithelial cell differentiation.


Past or Present Projects Available:

Role of the Epidermal Growth Factor Receptor and its ligands in mechanical stretch-induced lung injury; Role of the Epidermal Growth Factor Receptor (EGFR) and its ligands in mechanical stretch-induced lung injury