Research Opportunities Database

Edward Stopa

Edward Stopa

Professor of Pathology & Laboratory Medicine and Professor of Neurosurgery

Department: Pathology & Laboratory Medicine

Phone: +1 401 444 5057

Email: Edward_Stopa@Brown.EDU

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Location:

RI Hospital; Phone: 444-5057; Email: Edward_Stopa@Brown.edu

Research Summary

Alzheimer's disease (AD) is generally regarded as a degenerative disease, but many normal physiological processes are increased in AD patients. My research deals with proteins involved in three major physiological processes in the brain: cell growth and differentiation; maintaining the environment between neurons (the extra-cellular matrix); and the inflammatory response.

Past or Present Projects Available:

Expression of aquaporin-4 and endothelial cell tight junction proteins following over expression or loss of agrin; Evidence for early hydrocephalus and enhanced amyloid accumulation in the setting of FGF2 overexpression; Altering expression of Endothelial Agrin influences Aquaporin 4 expression in the capillary endothelial basement membrane of APP(sew)PS1(ex9) transgenic; Effects of pro-inflammatory cytokine IL-6 on tight junction proteins of the blood-brain barrier and potential attenuation by anti-IL-6 neutralizing