Research Opportunities Database

Gerwald Jogl

Gerwald Jogl

Associate Professor of Biology

Department: Molecular Biology, Cell Biology, & Biochemistry

Phone: 401-863-6123

Email: Gerwald_Jogl@brown.edu

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Location:

70 Ship Street, Room 129 - 863-6123

Research Summary

This lab uses X-ray crystallography as its main research tool (together with biochemical and biophysical approaches) to study the structure and function of proteins and macromolecular complexes.

The overall goal of the research is to understand the molecular mechanism of antibiotic resistance caused by mutations in bacterial ribosomes and to evaluate the contribution of post-transcriptional rRNA modifications for ribosome function and antibiotic resistance.

Past or Present Projects Available:

Biochemical studies of Phosphatidylinositol Transferases; Crystal structures of Thermus thermophilus rRNA modifying enzymes 1387 and 1353 with cofactor and substrate; Structural Studies of Decaprenylphosphory 1-B-D-ribose 2'-epimerase (DprE); Preparation of mutant 30S ribosomal subunits from Thermus thermophilus; Expression and purification of bacterial translational factors (IF1, IF2, IF3, EF-G, EF-Tu); Crystallization of bacterial ribosomal subunits and ribosomes.