Research Opportunities Database

William Fairbrother

William Fairbrother

Associate Professor of Biology

Department: Molecular Biology, Cell Biology, & Biochemistry

Phone: +1 401 863 6215

Phone 2: +1 401 863 6215

Email: William_Fairbrother@brown.edu

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Location:

70 Ship Street, Room 404 - 863-6215

Research Summary

Studies RNA splicing. A third of all hereditary disease mutations affect RNA splicing. Using deep sequencing and array based synthesis, we are measuring the effects of thousands of mutations and SNPs on splicing, spliceosome assembly and RNA protein binding. In the lab there is a strong emphasis on developing hybrid approaches to science, combining genome analysis and computational biology with experimentation

Past or Present Projects Available:

Large Scaled Genomic Analysis of Gene Expression Signals; Cross-Species Conservation of Gene Splicing Signals; Building a Splicing Simulator; Further Characterization of Functional Elements-experimental identification of trans-acting factors; Identifying Functional SNPs (in the brain); Running red lights--a search for stop codes readthrough in Drosophila and human genomes; The effect of secondary structure formation on RNA splicing in fish genes; UV crosslinking analysis of PTB ligands; High-throughput investigation of transcription factor binding for gene regulation and splicing; The Effect of SNPs on Post-Transcriptional; Identification of SNPs that--in Interfering with RNA splicing, cause Human Disease