Research Opportunities Database

Stephen Helfand

Stephen Helfand

Professor of Biology

Department: Molecular Biology, Cell Biology, & Biochemistry

Phone:

Phone 2: +1 401 863 1615

Email: Stephen_Helfand@brown.edu

Read Full Faculty Profile

Location:

Sidney Frank Hall, Room 164 - 863-1615

Research Summary

Understanding the molecular, cellular and genetic mechanisms underlying the process of aging and the determination of life span using the fruit fly, Drosophila melanogaster, as a model system.

Past or Present Projects Available:

Authophagy and Aging: Down regulating autophagy in the nervous system and fat-body of D. melanogaster; A genetic dissection of the life span extending effects of Nee-1 in D.melanogaster; Determining the key players in a pathway crucially affected during pharmacologically induced lifespan extension using necrsotatin-1; Examination of sirtain expression and its effects on aging; Determining the specificity of linamerin's toxic effect in photoreceptors selectively expressing linamarase in D. melanogaster; The role of IMD pathway components in Drosophila lifespan extension; Computational analysis of microarray data in the aging fly; The effects of Fox-o and Thor pathways with calorie restriction on D. melanogaster; Role of the histone deacetylase SIRT6 in D. melanogaster aging; The Effects of ADAR on Lifespan; Chromatin Changes during Aging