Research Opportunities Database

Gideon Koren

Professor of Medicine

Department: Medicine

Phone: +1 401 444 4629

Email: Gideon_Koren@brown.edu

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Location:

RIH, One Hoppin St. - Cardiology Division - 444-4629

Research Summary

We hypothesize that targeting of channels to particular membrane microdomains and their organization in macromolecular complexes allow cells to increase the efficiency of their response to extracellular signals.

Past or Present Projects Available:

Understanding the pathogenesis of cardiac arrhythmias; Genomic studies to elucidate the transcriptional program(s) that control the expression of membrane polypeptides involved in determining the duration of cardiac action potential and early and late after-depolarizations, as well as the aging of th heart; Investigation of the trafficking and localization of voltage-gated potassium channels in the cardiomyocytes; Creation of genetically modified animal; models for studying sudden cardiac death; The role of mycrocardial infraction and congestive heart failure in development of ventribular fibrillation; An analysis of the pro-arrhythmic effect of chronic estradiol treatment in LQT2 transgenic rabbits; Mechanisms of ventricular fibrilliation (VF) in a pacing-induced congestive heart failure (CHF); Protemics analysis of hormone-treated LQT2 rabbits; Assessing the expression and interactions of the cardiac potassium channels KCNQ1 and hERG; Differential Expression for Orphans and Vulnerable Children in South Africa; Regulation of Calcium-Induced Release by MicroRNA miR-208 in Cardiac Disease; The effect of stero-hormones, estradiol and progesterone on calcium cycling and sudden cardiac death in LQT2; Hormone Modulation of Cardiac Repolarization in LQT2 Rabbits