Research Opportunities Database
Assistant Professor of Pediatrics
Phone: +1 401 274 1122
Location:Women & Infants' - 401-274-1122 x7438; email@example.com
Research SummaryInterested in developing novel approaches to the diagnosis and treatment of preterm birth. Specifically, we have developed a mouse model of preterm birth based on the genetic ablation of the proteoglycans biglycan and decorin and are utilizing it to discover novel mechanisms leading to preterm birth.
Past or Present Projects Available:The influence of biglycan and decorin expression on matrix metalloprotease (MMP) activity and its implications for preterm birth.
Fetal membrane morphology in the biglycan/decorin double knockout mouse compared to the wild-type.
Future projects may include:
The contribution of biglycan and decorin to fetal membrane biomechanical functions.
A gene-environment interaction preterm birth model: Inflammation compounding the underlying genetic defect in pregnant biglycan/decorin knockout mice.
TGF-beta signaling pathway interactions with biglycan and decorin and its implications for preterm birth.