Research Opportunities Database

Zoltan Derdak

Assistant Professor of Medicine (Research)

Department: Medicine

Phone: +1 401 444 8654

Email: Zoltan_Derdak@Brown.EDU

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Research Summary

The role of p53 in alcoholic (ALD) and non-alcoholic (obesity-associated) fatty liver disease (NAFLD).
Both diseases are characterized by hepatocellular apoptosis, oxidative stress, insulin resistance and steatosis (excess fat accumulation).

Past or Present Projects Available:

1. The p53 inhibitor, pifithrin-alpha p-nitro attenuates non-alcoholic fatty liver disease in mice

1. Pifithrin-alpha p-nitro reduces liver injury and steatosis in chronically ethanol-fed rats
2. The role of p53 in cellular fatty acid metabolism and insulin signaling